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(USMLE topics) Methamphetamine: mechanism of action, short-term and long-term effects, addiction and overdose. This video is available for instant download licensing here : https://www.alilamedicalmedia.com/-/galleries/narrated-videos-by-topics/addiction-science/-/medias/0cb9ae40-98c9-4d9a-b812-cba7dd929585-methamphetamine-meth-narrated-animation
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Methamphetamine, also called meth or crystal meth, among other names, is a psychostimulant drug mainly known for its recreational use. Methamphetamine is chemically similar to amphetamine, a drug used to treat attention-deficit hyperactivity disorder, obesity and narcolepsy; but being more potent and highly addictive, methamphetamine is rarely prescribed for medical treatments. Most commonly, the drug is produced illegally, from pseudoephedrine, an ingredient in cold medicines. It can exist as white powder, pills, or bluish-white crystals, and can be consumed by swallowing, smoking, snorting, or injecting.
Methamphetamine acts to increase the amount of a neurotransmitter called dopamine in the brain. Dopamine is at the basis of the brain reward pathway, which is designed to “reward” the body for important behaviors that are essential for survival, such as feeding when hungry. Engaging in enjoyable activities causes dopamine release from dopamine-producing neurons into a space between neurons, where it binds to and stimulates its receptors on the neighboring neuron. This stimulation is believed to produce pleasurable feelings or rewarding effect.
Normally, dopamine molecules are promptly cleared from the synaptic space to ensure that the postsynaptic neurons are not over-stimulated. This is possible thanks to the action of dopamine-transporter, which channels dopamine back to the transmitting neuron.
Methamphetamine binds to dopamine-transporter and blocks dopamine re-uptake. In addition, it can enter the transmitting neuron and trigger more dopamine release. The result is that dopamine builds-up in the synapse to a much greater amount than normal. This produces a continuous over-stimulation of receiving neurons and is responsible for the prolonged and intense euphoria experienced by drug users.
At a low dose, methamphetamine stimulates the brain and can elevate mood and alertness; and by accelerating heart rate and breathing rate, it increases energy in fatigued individuals. It also reduces appetite and promotes weight loss. These seemingly “positive” effects keep users coming back for more, eventually leading to addiction and potential overdose. Long-term drug users may experience extreme weight loss, severe dental damage, and constant hyperactivity which results in anxiety, sleeping disorders and violent behaviors.
Overdose takes the drug’s effects to the extreme and can cause psychosis, heart attacks, seizures, strokes, organ failures, and even death.
Currently, there is no approved pharmacological treatment for methamphetamine addiction; the most effective treatments are cognitive behavioral therapies.
Alcoholic Ketosis Wikem, Methamphetamine (meth) Drug Facts, Animation.
Reduce Weight – Fat Utilizing Ketosis Diet
Lots of research studies have shown that this diet plan is developed to work. I don’t find this needed and in many cases I find it to be an error. I will further discuss these things in the following post.
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How Much Weight Do You Lose On Medifast Per Week?
What I didn’t inform you yet, is that ketosis is treated by a huge part of the medical society as a bodily crisis. The meals are really simple to prepare and some just need that you eliminate the wrapper.
I wished to speak with you about how you can shed pounds with periodic fasting. There are a lot of individuals searching for a method to slim down. It can be tough due to the fact that there are so numerous various diet plans out there, so how do you understand which ones truly work and will generate results. Intermittent fasting isn’t your standard kind of diet plan since it does not limit what you consume. You can consume all the unhealthy food and grease you desire because that is not how it is structured. It is structured to have durations of eating and durations of fasting, that makes it a powerful mix. I’m here to talk to you about how you can shed pounds with intermittent fasting.
That’s right. 48 hour fasting ketosis is a great way to begin reducing weight, specifically if you have a great deal of body fat. In reality, some individuals go into ketosis even on ‘routine’ diets, because they are still eating less. And, as an outcome, a number of them not just look much better, but they likewise feel more stimulated.
Just recently a substantial ketogenic diet thirst variety of individuals have actually began to use diet plan by Dr.Atkins, and the last outcomes that great deals of them accomplished have actually produced a big publicity.
The Atkins Diet has actually suffered a great deal of criticism in the past, generally declaring that Atkins is bad for you. There are many myths to dispel. To be truthful, whilst it is a fairly drastic modification in diet which alters your metabolism, it isn’t really that bad. Many individuals who criticise the diet don’t really comprehend how it works.
Another type of workout is weightlifting. Weight lifting is not as effective and immediate as cardio training, however it does work in the long run. By developing muscle mass, your muscles will use more calories as you lift. Weight lifting is not a significant for of calorie burning, so it’s a good concept to integrate cardiovascular workouts to get the very best nutritional ketosis information outcomes.
Researchers have actually discovered that a test group who took part in a 20-minute circuit strength-training session burned 25% as many calories after their workout as they did throughout it. They likewise found that such exercise elevated the resting metabolic rate for more than 12 hours after the exercise.
To compute your BMR to control your day-to-day calories, you can utilize this BMR calculator. Remember, nevertheless, that this is just a guide to identify your calorie consumption. After a week, examine your progress and make whatever modifications are needed.
Experiment a bit and find a few healthy proteins that you like. The designs or actors did not attain their fit bodies from the fast, easy “magical option” promoted. I think that makes it a considerable kind of diet plan.
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